Nigrostriatal dopaminergic depletion increases static orofacial allodynia
نویسندگان
چکیده
منابع مشابه
Lesion of the dopaminergic nigrostriatal pathway induces trigeminal dynamic mechanical allodynia
BACKGROUND Pain constitutes the major non motor syndrome in Parkinson's disease (PD) and includes neuropathic pain; however current drug therapies used to alleviate it have only limited efficacy. This is probably due to poor understanding of the mechanisms underlying it. AIMS We investigated a major class of trigeminal neuropathic pain, dynamic mechanical allodynia (DMA), in a rat model of PD...
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A degeneration of the nigrostriatal pathway is a primary component of Parkinson's disease (PD), and we have investigated the actions of insecticides on this pathway. For in vivo exposures, C57BL/6 mice were treated three times over a 2-week period with heptachlor, the pyrethroids deltamethrin and permethrin, or chlorpyrifos. One day after the last treatment, we observed that heptachlor and the ...
متن کاملClinical Features Indicating Nigrostriatal Dopaminergic Degeneration in Drug-Induced Parkinsonism
OBJECTIVE Patients with drug-induced parkinsonism (DIP) may have nigrostriatal dopaminergic degeneration. We studied the clinical features that may indicate nigrostriatal dopaminergic degeneration in patients with DIP. METHODS Forty-one DIP patients were classified into normal and abnormal [18F] FP-CIT scan groups. Differences in 32 clinical features and drug withdrawal effects were studied. ...
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ژورنال
عنوان ژورنال: The Journal of Headache and Pain
سال: 2016
ISSN: 1129-2369,1129-2377
DOI: 10.1186/s10194-016-0607-z